Dear Colleagues and Students,
You are cordially invited to UNAM Nanocolloquium seminars focusing on advancements in the field of nanoscience and nanotechnology. The seminars bring us the most recent developments in these exciting fields.
The talk will be presented by Asst. Prof. Ömer Yılmaz*
Title: Deconstructing the early steps of obesity-mediated intestinal tumorigenesis
Date: April 22, 2016 (Friday)
Place: UNAM Conference Room
ABSTRACT – Organismal diet has a profound impact on tissue regeneration, aging, and disease in mammals. However, the mechanisms through which diet perturbs stem and progenitor cell biology and leads to diseases, such as cancers are poorly understood. With the rise of obesity in the US population – more than 1 in 3 adults are obese – understanding the relationship between diet, stem cell biology, and
cancer incidence takes on great importance. From epidemiologic data, it has been long observed that obesity correlates with augmented cancer incidence in humans.
Yet, little is known about how diets that lead to obesity such as a high fat diet (HFD) regulate adult stem and progenitor cell function and how a HFD influences the vulnerability of these cells to undergo oncogenic transformation to form tumors.
Our lab is interested in understanding how a pro-obesity HFD alters the biology of intestinal stem cells (ISCs) and progenitors, and how such changes contribute to the early steps of intestinal tumorigenesis.
*Massachusetts Institute of Technology, USA
Next week seminar:
April 29 – Bart Jan Ravoo, Organic Chemistry Institute Westfalische Wilhelms Universitat, Münster, Germany
All interested are cordially invited!