UMRAM ve Beyin Ara\u015ft\u0131rmalar\u0131 Merkezi N\u00f6robilim Semineri<\/p>\n
\u201cKendini Yeme Nas\u0131l \u00d6d\u00fcllendirilebilir: Yeni Bir Kokain Resept\u00f6r\u00fcn\u00fcn Hikayesi\u201d<\/p>\n
Dr. Maged Harraz
\nJohns Hopkins \u00dcniversitesi<\/p>\n
Tarih\/Zaman: 13 \u015eubat, Per\u015fembe 12:40
\nYer: Seminar Odas\u0131, SC 106<\/p>\n
\u00d6zet: Kokainin uyar\u0131c\u0131 etkileri y\u00fczy\u0131l\u0131 a\u015fk\u0131n bir s\u00fcredir incelenmesine ra\u011fmen, molek\u00fcler etki mekanizmas\u0131 \u015fa\u015f\u0131rt\u0131c\u0131 bir \u015fekilde asla titizlikle tasvir edilememi\u015ftir. Bir\u00e7ok laboratuvar, kokain taraf\u0131ndan biyojenik amin al\u0131m\u0131n\u0131n inhibisyonunu (\u00f6zellikle dopamin) bildirmi\u015ftir. Ancak, kokain, dopamin ta\u015f\u0131y\u0131c\u0131s\u0131n\u0131n (DAT) nispeten zay\u0131f, mikromolar bir inhibit\u00f6r\u00fcd\u00fcr. \u015eimdiki \u00e7al\u0131\u015fmalar\u0131m\u0131zda, kokainin farmakolojik olarak alakal\u0131 bir kokain resept\u00f6r\u00fcn\u00fc temsil eden BASP1 proteinine ola\u011fan\u00fcst\u00fc y\u00fcksek afinite ile ba\u011fland\u0131\u011f\u0131n\u0131 bildiriyoruz. BASP1’in t\u00fckenmesi kokainin psikoaktif etkilerini \u00f6nlemektedir. Kokain BASP1 arac\u0131l\u0131\u011f\u0131yla n\u00f6ronal otofajiyi (h\u00fccresel homeostatik kendi kendine bozunma s\u00fcreci) uyarmak i\u00e7in etki etmektedir. Otofaji, s\u0131rayla, DAT’yi se\u00e7ici olarak bozunma i\u00e7in hedefleyerek dopamin geri al\u0131m\u0131n\u0131 engeller. Otofajinin farmakolojik inhibit\u00f6rleri, kokainin davran\u0131\u015fsal eylemlerini ortadan kald\u0131r\u0131r. Kokainin psikoaktivite modunu a\u00e7\u0131klamam\u0131z uyu\u015fturucu ba\u011f\u0131ml\u0131l\u0131\u011f\u0131 i\u00e7in terap\u00f6tik ajanlar\u0131n geli\u015ftirilmesini kolayla\u015ft\u0131rabilir. \u015eu ana kadarki bulgular\u0131m\u0131z, kokainin sinaptik plastisitenin alt\u0131nda yatan sinyal sistemleri yoluyla hareket etti\u011fini g\u00f6stermektedir, bu bulgular \u00f6\u011frenme ve haf\u0131zan\u0131n \u00f6zelliklerini ortaya \u00e7\u0131karmaya da yard\u0131mc\u0131 olabilir.<\/p>\n
K\u0131sa \u00d6zge\u00e7mi\u015f: Dr. Maged Harraz t\u0131p ve y\u00fcksek lisans derecelerini M\u0131s\u0131r’daki S\u00fcvey\u015f Kanal\u0131 \u00dcniversitesi’nden ald\u0131. Sonra ABD’ye ta\u015f\u0131nd\u0131 ve lisans\u00fcst\u00fc e\u011fitim i\u00e7in Iowa \u00dcniversitesi’ne kat\u0131ld\u0131. Doktora \u00e7al\u0131\u015fmalar\u0131, n\u00f6rodejenerasyona katk\u0131da bulunan yeni bir molek\u00fcler mekanizma belirlenmesine \u00f6nc\u00fcl\u00fck etmi\u015ftir. Dr. Harraz, doktora sonras\u0131 e\u011fitim i\u00e7in Ted ve Valina Dawson’\u0131n Johns Hopkins \u00dcniversitesi\u2019ndeki laboratuvar\u0131na kat\u0131ld\u0131. Bu \u00e7al\u0131\u015fmalar\u0131 n\u00f6ronal geli\u015fim, uyar\u0131labilirlik ve dejenerasyonun microRNA reg\u00fclasyonu \u00fczerine odaklanm\u0131\u015ft\u0131r. Daha sonra, Ara\u015ft\u0131rmac\u0131 olarak Solomon Snyder grubuna kat\u0131l\u0131p, burada glutamat resept\u00f6r\u00fcn\u00fc mTOR sinyaline ba\u011flayan bir molek\u00fcler kaskad\u0131n\u0131 karakterize etmi\u015ftir ve omigapili h\u0131zla hareket eden bir antidepresan olarak tan\u0131mlam\u0131\u015ft\u0131r. \u015eu anda, Dr. Harraz kokain i\u00e7in yeni bir y\u00fcksek afiniteli resept\u00f6r\u00fc karakterize etmeye odaklanmaktad\u0131r. Maryland \u0130novasyon Giri\u015fimi Proje Deste\u011fi, Johns Hopkins \u00dcniversitesi Ke\u015fif \u00d6d\u00fclleri ve Beyin ve Davran\u0131\u015f Vakf\u0131’ndan NARSAD Gen\u00e7 Ara\u015ft\u0131rmac\u0131 Deste\u011fi gibi bir\u00e7ok \u00f6d\u00fcle lay\u0131k g\u00f6r\u00fcld\u00fc.<\/p>\n","protected":false},"excerpt":{"rendered":"
UMRAM ve Beyin Ara\u015ft\u0131rmalar\u0131 Merkezi N\u00f6robilim Semineri \u201cKendini Yeme Nas\u0131l \u00d6d\u00fcllendirilebilir: Yeni Bir Kokain Resept\u00f6r\u00fcn\u00fcn Hikayesi\u201d Dr. Maged Harraz Johns Hopkins \u00dcniversitesi Tarih\/Zaman: 13 \u015eubat, Per\u015fembe 12:40 Yer: Seminar Odas\u0131, SC 106 \u00d6zet: Kokainin uyar\u0131c\u0131 etkileri y\u00fczy\u0131l\u0131 a\u015fk\u0131n bir s\u00fcredir incelenmesine ra\u011fmen, molek\u00fcler etki mekanizmas\u0131 \u015fa\u015f\u0131rt\u0131c\u0131 bir \u015fekilde asla titizlikle [\u2026] <\/p>\n