{"id":20861,"date":"2020-12-31T20:34:41","date_gmt":"2020-12-31T17:34:41","guid":{"rendered":"https:\/\/w3.bilkent.edu.tr\/tr\/?page_id=20861"},"modified":"2021-09-07T16:40:52","modified_gmt":"2021-09-07T13:40:52","slug":"diagnovir","status":"publish","type":"page","link":"https:\/\/w3.bilkent.edu.tr\/tr\/diagnovir\/","title":{"rendered":"Diagnovir"},"content":{"rendered":"

Unam’da COVID-19 Testini %99 do\u011fruluk oran\u0131yla 10 saniyede ger\u00e7ekle\u015ftiren yeni tan\u0131 sistemi\u00a0 geli\u015ftirildi.<\/p>\n

Bilkent \u00dcniversitesi UNAM’\u0131n altyap\u0131s\u0131nda, Dr. \u00d6\u011fr. \u00dcyesi B\u00fclend Orta\u00e7 ve ekibi, Bilkent Holding ve Bilkent Cyberpark Teknoloji Geli\u015ftirme B\u00f6lgesi\u2019nde faaliyet g\u00f6steren E-A Teknoloji\u2019nin ortak \u00e7al\u0131\u015fmas\u0131 sonucu, yeni tip koronavir\u00fcs (Kovid-19\/SARS Cov2) tespitinde kullan\u0131labilecek \u2018in vitro\u2019 bir vir\u00fcs tan\u0131 sistemi geli\u015ftirildi.<\/p>\n

T\u00fcrkiye\u2019de ilk vakan\u0131n g\u00f6r\u00fclmesini m\u00fcteakip kurulan i\u015fbirli\u011fi alt\u0131nda 7 ayd\u0131r s\u00fcren \u00e7al\u0131\u015fmalar netice vermi\u015f ve \u00e7\u0131kan sonu\u00e7lar y\u00fczleri g\u00fcld\u00fcrm\u00fc\u015ft\u00fcr.<\/p>\n

\"\"<\/a>Nanoteknoloji temelli yeni tan\u0131 sistemi, COVID-19 vir\u00fcs\u00fcn\u00fc, a\u011f\u0131z i\u00e7inden al\u0131nan s\u00fcr\u00fcnt\u00fc \u00f6rne\u011fi ile 10 saniye i\u00e7inde tespit edebilmektedir. Diagnovir, vir\u00fcs\u00fcn varl\u0131\u011f\u0131nda \u0131\u015f\u0131ma rengi de\u011fi\u015fen, bu sayede y\u00fcksek se\u00e7icilikte vir\u00fcs tespiti yapabilen optik temelli bir te\u015fhis ve tan\u0131 sistemidir. Bu sistemde, bir biyosens\u00f6r cihaz\u0131na \u00f6zel olarak geli\u015ftirilen patojen tespit \u00e7ipi \u00fczerinden, dinamik olarak floresan sinyali al\u0131narak, patojenlerin en fazla 10 saniye i\u00e7erisinde tespit edilmesi sa\u011flanmaktad\u0131r. Bir hastadan al\u0131nan \u00f6rnek, \u00f6zel bir sol\u00fcsyonla kar\u0131\u015ft\u0131r\u0131ld\u0131ktan sonra patojen tespit \u00e7ipi\u00a0 \u00fczerine damlat\u0131lmakta, biyosens\u00f6r cihaz\u0131 taraf\u0131ndan ortamda patojen varsa, floresan sinyali al\u0131narak y\u00fcksek do\u011frulukta patojen varl\u0131\u011f\u0131 tespit edilmektedir. Halihaz\u0131rda orofarenks ve nazofarenks gibi derin b\u00f6lgelerden s\u00fcr\u00fcnt\u00fc \u00f6rne\u011fi almak yerine, a\u011f\u0131z i\u00e7inden t\u00fck\u00fcr\u00fck \u00f6rne\u011fi al\u0131nmas\u0131 da sistemin kullan\u0131m\u0131n\u0131 tercih edilir k\u0131lacakt\u0131r. Yayg\u0131n olarak kullan\u0131lan PCR testlerinden farkl\u0131 olarak, sistem \u00f6rnek \u00e7o\u011faltmaya de\u011fil, geli\u015fmi\u015f optik y\u00f6ntemlerle vir\u00fcs\u00fcn varl\u0131\u011f\u0131 ya da yoklu\u011funun tespitine dayanmaktad\u0131r. Sistemde hem hassas bi\u00e7imde vir\u00fcs tespitini, hem de tespitte y\u00fcksek derecede se\u00e7icili\u011fi sa\u011flayan optik ve elektronik mod\u00fcller, ayr\u0131ca \u00fcst d\u00fczey biyoteknoloji ve malzeme bilimi bilgisi kullan\u0131lm\u0131\u015ft\u0131r. Sistem \u015fimdiye kadar yap\u0131lan \u00f6n klinik \u00e7al\u0131\u015fmalarda, vir\u00fcs tespitinde %99 ba\u015far\u0131 g\u00f6stermi\u015ftir. H\u0131zl\u0131 ve g\u00fcvenilir bir vir\u00fcs tespit y\u00f6ntemi olarak, sistemin \u00fclkemizde ve d\u00fcnyada yayg\u0131n olarak kullan\u0131laca\u011f\u0131na inan\u0131lmaktad\u0131r. Dolay\u0131s\u0131yla bu biyosens\u00f6r sisteminin seri \u00fcretimi i\u00e7in gerekli altyap\u0131 yat\u0131r\u0131mlar\u0131na halihaz\u0131rda ba\u015flanm\u0131\u015ft\u0131r. Etik Kurul onay\u0131 ve T\u00fcrkiye \u0130la\u00e7 ve T\u0131bbi Cihaz Kurumu (T\u0130TCK) onay\u0131 gibi\u00a0 gerekli izinlerin ek k\u0131sa s\u00fcrede tamamlanarak, \u00fcr\u00fcn\u00fcn seri \u00fcretim safhas\u0131na ge\u00e7ilmesi ve tahminen 2 ay i\u00e7erisinde kullan\u0131c\u0131larla bulu\u015fturulmas\u0131 planlanmaktad\u0131r.<\/p>\n

Diagnovir ismi verilen sistem, tamam\u0131yla yeni bir teknolojik altyap\u0131ya sahip bir bulu\u015ftur. Bu yenili\u011fin fikri haklar\u0131n\u0131 koruma amac\u0131yla sistemin patent ba\u015fvurular\u0131 da ge\u00e7ti\u011fimiz g\u00fcnlerde yap\u0131lm\u0131\u015ft\u0131r. Bu ba\u015far\u0131l\u0131 \u00fcr\u00fcn\u00fcn geli\u015ftirilmesine olanak sa\u011flayan teknoloji, farkl\u0131 konularda uzmanl\u0131\u011fa sahip olan ve ortak bir ama\u00e7 etraf\u0131nda \u00e7ok ba\u015far\u0131l\u0131 bir tak\u0131m \u00e7al\u0131\u015fmas\u0131 ger\u00e7ekle\u015ftiren T\u00fcrk ara\u015ft\u0131rmac\u0131lar taraf\u0131ndan, b\u00fcy\u00fck oranda Bilkent \u00dcniversitesi ve UNAM b\u00fcnyesinde ve Bilkent Cyberpark\u2019ta geli\u015ftirilmi\u015f, ayr\u0131ca Bilkent UNAM altyap\u0131s\u0131 kullan\u0131lm\u0131\u015ft\u0131r. Sistem y\u00fcksek ihracat potansiyeli ta\u015f\u0131maktad\u0131r.\u00a0 Yurti\u00e7i ve yurtd\u0131\u015f\u0131nda sat\u0131\u015f\u0131n \u00f6n\u00fcn\u00fc a\u00e7acak t\u00fcm i\u015faretleme, belgelendirme ve akreditasyon ad\u0131mlar\u0131na da ba\u015flanm\u0131\u015f durumdad\u0131r.<\/p>\n

T\u00fcrk ara\u015ft\u0131rmac\u0131lar taraf\u0131ndan, Bilkent \u00dcniversitesi UNAM b\u00fcnyesinde ve altyap\u0131s\u0131nda geli\u015ftirilen bu sistemin amac\u0131 her ne kadar COV\u0130D-19 vir\u00fcs tespiti olsa da, ileride yap\u0131lacak \u00e7al\u0131\u015fmalar ile \u00e7e\u015fitli patojen tespitleri i\u00e7in de kullan\u0131labilecektir.<\/p>\n